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Aseptic Powder Filling

Aseptic Powder Filling

We are becoming increasingly reliant on drugs that need to be sterile and produced via aseptic processing. 3P has a wide range of standard aseptic fill-finish equipment at a range of scales.

3P also has a rich heritage in pharmaceutical powder micro-dosing and filling technologies originally developed to support the inhalation market. 3P therefore has a somewhat unique offering in the niche market of aseptic powder fill-finish.

Most parenteral application involve the fill-finish of a liquid. To avoid what are known as cold-chain challenges or to provide sustained release, parenteral applications increasingly require powder fill-finish. These powders are typically reconstituted with a diluent prior to administration 

3P's excels in pharmaceutical powder micro-dosing and filling technologies specialising and in applying these in the aseptic manufacturing environments.  We offer several 'off-the-shelf' solutions and also design and manufacture custom solutions if the product and process demands it.  Aseptic powder filling brings many technical challenges. These include accurate weighing, particulate control, ergonomics, managing electro-statics, bulk powder handling, sealing and cleanability.  Our engineers bring decades of experience to address these challenges.

We have wide range of aseptic technologies that precisely dispense from milligrams to grammes of powder. Take a closer look at some of our powder filling technologies by following the links to Fill2WeightVF1 Vibratory Feeder and Micro-Auger.  Each of these can be applied in a lab-scale, semi-automated or fully-automated machine setting. All our powder filling technologies can include 100% weight verification.

Fill2Weight is our award-winning, patented solution for the micro-dosing of powders down to 1mg.  It excels in handling the most challenging of powders, including delicate biologics, spray-dried formulations, bulk-lyophilised powders and blends where careful handling is essential to prevent segregation and separation of drug ingredients.  The technology has been successfully applied in automated aseptic processing production lines, filling reconstitution syringes, cartridges, vials and custom primary drug containers for emergency auto-injectors.

Contact us today to book time in our powder laboratory to carry out screening trials with your powder on a range of dispensing equipment.

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