Skip to the main content.

Fill2Weight Gravimetric Powder Filler

Fills syringes, vials, cartridges, capsules and custom containers with the World's fastest gravimetric powder micro-dosing technology.

Engineered for pharmaceutical and biotech applications, Fill2Weight meets the demand for low-volume cGMP manufacturing and high flexibility. It excels in handling ultra-low-dose, high-potency APIs and offers precise powder filling for inhalation, parenteral, and OSD applications in sterile environments.

Innovative and precise, it ensures smooth powder flow without compaction, preserving drug efficacy for inhalation. Localised low-frequency vibration prevents blend segregation or damage, ensuring consistent, high-quality results.

Reduce lead times

Our system handles even the most challenging powders, eliminating the need for costly, time-consuming formulation development. Customers reach 'first-in-human' (FIH) milestones 2-3 months faster, gaining earlier insights into drug efficacy. This accelerates launches, boosts ROI, and frees up capacity to develop more products.

Dose Sub1 mg

The Gravimetric Filler can dose very small quantities of powder; the need for smaller doses is driven by the development of high-potency drugs and desire to administer drugs in pure API form.

Key Benefits include:

  • Gravimetric powder filling:  100% weight verification and faster cycle times with high-precision dosing
  • Scalable technology:  Identical systems used in our fully-automated, higher-speed machines.
  • Handles and fills the most challenging powders (including delicate biologics, spray-dried and freeze-dried, blends, micro-spheres and engineered particles)
  • Isolator ready:  Aseptic, GMP design
  • Entry-level system:  Cost-effective, with short lead-times.
  • Suitable for spray dried and lyophilised powders
  • Autoclavable dispensing head
  • Tool-less disassembly for cleaning and sterilisation
  • Suitable for VHP environments
  • Ultra-compact and portable:  Use inside existing isolators, RABS, LAF’s and down-flow booths.**

** Subject to size of enclosure

Minimal drug product required and zero waste

In early stages of a new development, very low quantities of API are available as manufacture is carried out with lab-scale methods. The filler works with very small quantities of powder. Just 2-3 grams is sufficient to enable doses to be created for administration to patients or for other development tests. Unused powder can be recovered, meaning zero waste.

Improved product quality and patient safety

The fillers gravimetric system means that every dose is verified and any doses outside limits are rejected. Precision weighing enables tighter tolerances, meaning smaller doses can be dispensed. This is essential for high-potency drugs, where inaccurate dosing poses risks to patient safety.

Enables filling of biologics and engineered particles

The Gravimetric Filler enables dosing of new drugs in a form previously not possible. Delicate, ‘long-chain’ biologics and ‘engineered’ particles made with technologies such as spray-drying are typically unsuitable for volumetric dosing, but can be dosed successfully with Fill2Weight.

 

Configurable dose

1mg to 5000g

Dosing accuracy

<3 % RSD

Dosing cycle time

2 to 7 seconds

Dimensions

H 880 X W 250 X D 450 mm

Hopper capacity

7000mg + bulk feeding option

 

Scalable for total-lifecycle support

All of our core technology is scalable, ensuring that your early-stage clinical processes can be scaled up for commercial production. This means you won't need to develop and validate costly new technologies with each scale-up.

Fill2Weight can be integrated into our larger, Robotic Capsule Filler, capable of filling up to 500 or even 1000 capsules per hour. Additionally, we can integrate Fill2Weight into a fully autonomous isolator, the Robotic Fill-Finish Cell. 

123-1
F2V tablet slides

Fill2Weight Gravimetric Filler

 

r500

Robotic Capsule Filler

R2 no background

Robotic Fill-Finish Cell Pro