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Fill2Weight Gravimetric Powder Filler

Fills syringes, vials, cartridges, capsules and custom containers with the World's fastest gravimetric powder micro-dosing technology.

Engineered for pharmaceutical and biotech applications, Fill2Weight meets the demand for low-volume cGMP manufacturing and high flexibility. It excels in handling ultra-low-dose, high-potency APIs and offers precise powder filling for inhalation, parenteral, and OSD applications in sterile environments. Every dose is weighed, verified, and any out-of-spec doses are rejected, ensuring the highest quality standards.

At its core, Fill2Weight works by fluidising powder and reacting to weigh cell feedback during dosing to alter its dispensing rate.
Piezo-actuated vibration and stirring fluidises the powder, and the combination of dosing pin opening and vibration amplitude controls the dispensing rate. Given the live weigh cell feedback, the control system 
then predicts when to close the dosing pin to achieve the target weight.

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Benefits

Reduce lead times: Our system handles even the most challenging powders, eliminating the need for costly, time-consuming formulation development. Customers reach 'first-in-human' (FIH) milestones 2-3 months faster, gaining earlier insights into drug efficacy. This accelerates launches, boosts ROI, and frees up capacity to develop more products.

Dose sub 1 mg: The Gravimetric Filler can dose very small quantities of powder; the need for smaller doses is driven by the development of high-potency drugs and desire to administer drugs in pure API form.

Applications

Parenteral / Aseptic
Fill2Weight® is perfect for parenteral and aseptic applications, where precision and sterility are critical. The technology enables highly accurate dosing of sterile powders directly into vials, cartridges and syringes, ensuring consistent fill weights without compromising sensitive formulations. All product contact parts are removable and autoclavable, with the entire system being compatible with VHP, ensuring your products are protected. With proven success with advanced formulations such as spray-dried biologics and lyophilized vaccines, it enables pre-clinical development through to commercial manufacture. Requiring as little as 2–3 grams of API with an excellent recovery rate, Fill2Weight® is especially valuable for orphan drugs and ultra-high value products where precision and material efficiency are essential. 

Inhalation
Fill2Weight® enables precise, reproducible filling of dry powders into capsules, blisters, oral and nasal inhaler devices, ensuring accurate dosing of everything from typical respiratory therapies through to inhaled biologics. It's gentle, vibration-based system maintains particle integrity without compaction, preserving drug efficacy and aerosolisation performance. From early-stage R&D to commercial production, it provides a flexible solution for challenging inhalation formulations, minimising product loss while maximising quality and consistency.

Scaling up?

All of our core technology is scalable, ensuring that your early-stage clinical processes can be scaled up for commercial production. This means you won't need to develop and validate costly new technologies with each scale-up. Fill2Weight can be integrated into our larger, Robotic Capsule Filler, capable of filling up to 500 or even 1000 capsules per hour. Additionally, we can integrate Fill2Weight into a fully autonomous isolator, the Robotic Fill-Finish Cell Pro. 

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Fill2Weight Gravimetric Filler

 

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Robotic Capsule Filler

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Robotic Fill-Finish Cell Pro